GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs2404602 | 1 | rs12443137 | chr15:76840832 | SCAPER | chr15:76640529-77197744:- | -0.2 | -4.46 | 1.08E-5 | Blood metabolite levels |
| BLCA | cis | rs7247513 | 1 | rs12459123 | chr19:12689741 | C19orf56 | chr19:12778881-12780465:- | 0.2 | 3.86 | 0.000134 | Bipolar disorder |
| BLCA | cis | rs7589728 | 1 | rs12473740 | chr2:88527647 | THNSL2 | chr2:88469835-88486145:+ | -0.57 | -5.69 | 2.53E-8 | Plasma clusterin levels |
| BLCA | cis | rs6087771 | 1 | rs12479491 | chr20:30265450 | COX4I2 | chr20:30225691-30232800:+ | 0.21 | 4.43 | 1.22E-5 | Subcortical brain region volumes |
| BLCA | cis | rs13053817 | 1 | rs12484859 | chr22:29844884 | NIPSNAP1 | chr22:29950800-29977144:- | 0.29 | 4.01 | 7.44E-5 | Carotid atherosclerosis in HIV infection |
| BLCA | cis | rs10935120 | 1 | rs12490835 | chr3:134223730 | ANAPC13 | chr3:134196547-134204865:- | 0.51 | 8.16 | 5.01E-15 | Height |
| BLCA | cis | rs10935120 | 1 | rs12490835 | chr3:134223730 | CEP63 | chr3:134204575-134293852:+ | 0.25 | 4.42 | 1.28E-5 | Height |
| BLCA | cis | rs11723261 | 1 | rs12505835 | chr4:297525 | ZNF718 | chr4:53272-156488:+ | 0.36 | 4.72 | 3.33E-6 | Immune response to smallpox vaccine (IL-6) |
| BLCA | cis | rs13256369 | 1 | rs12547721 | chr8:8570671 | CLDN23 | chr8:8559666-8561616:+ | -0.23 | -3.97 | 8.41E-5 | Obesity-related traits |
| BLCA | cis | rs13256369 | 1 | rs12550762 | chr8:8576535 | CLDN23 | chr8:8559666-8561616:+ | -0.23 | -4.07 | 5.62E-5 | Obesity-related traits |
| BLCA | cis | rs2275426 | 1 | rs12561806 | chr1:46396776 | CCDC163P | chr1:45960581-45965646:- | -0.35 | -6.56 | 1.75E-10 | Body mass index |
| BLCA | cis | rs2275426 | 1 | rs12564541 | chr1:46380237 | CCDC163P | chr1:45960581-45965646:- | -0.36 | -6.79 | 4.29E-11 | Body mass index |
| BLCA | cis | rs4953911 | 1 | rs1257200 | chr2:135036696 | RAB3GAP1 | chr2:135809853-135933964:+ | 0.19 | 3.85 | 0.000138 | Multiple sclerosis (severity) |
| BLCA | cis | rs4237643 | 1 | rs12577464 | chr11:43662440 | HSD17B12 | chr11:43702143-43878160:+ | -0.42 | -6.86 | 2.82E-11 | Forced vital capacity |
| BLCA | cis | rs2404602 | 1 | rs12594212 | chr15:76802014 | SCAPER | chr15:76640529-77197744:- | -0.21 | -4.52 | 8.36E-6 | Blood metabolite levels |